Monitoring of multidrug resistence in a human leukemic cell line by cytogenetic and molecular analysis

A study of cross-resistance pattern and

A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin

✍ Rosanna Supino; Monica Binaschi; Giovanni Capranico; Romolo A. Gambetta; Elena S 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 920 KB

## Abstract A doxorubicin‐resistant variant of the human small‐cell lung‐cancer cell line N592 was selected by __in vitro__ continuous exposure to increasing drug concentrations. The aim of this study was to examine the cross‐resistance pattern, cellular pharmacokinetics of doxorubicin and expressi

Regulation of expression of P-glycoprote

Regulation of expression of P-glycoprotein and gst by multidrug-resistant reversors in adm-sensitive and adm-resistant human tumor cell lines

✍ Zuofu Xie; Xiandong Lin; Dongmei Zhou; Sheng Lin 📂 Article 📅 1999 🏛 Chinese Anti-Cancer Association 🌐 English ⚖ 735 KB

Cytokines alter the expression and activ

Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays

✍ Gigi Lee; Micheline Piquette-Miller 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 1 views

Pro-inflammatory cytokines suppress the hepatic expression of the multidrug resistance transporters in rodents, indicating potential usefulness in chemotherapy. Our objective was to investigate their impact in human hepatoma cells. HuH 7 and HepG2 cells were treated with IL-1beta, IL-6, or TNF-alpha

Multidrug-resistant human kb carcinoma c

Multidrug-resistant human kb carcinoma cells are highly resistant to the protein phosphatase inhibitors okadaic acid and calyculin A. Analysis of potential mechanisms involved in toxin resistance

✍ Timothy C. Chambers; Robert L. Raynor; J. F. Kuo 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 750 KB

In this study we show that multidrug-resistant (MDR) human KB-VI cells are highly resistant to the cytotoxicity of okadaic acid and calyculin A, 2 toxins from marine sponges that are potent inhibitors of type-I and type-2A protein phosphatases (PPl and PP2A). Cytotoxicity and colony-forming assays i

Identification of anthracyclines and rel

Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

✍ Helen M. Coley; Peter R. Twentyman; Paul Workman 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 46 KB

Identification of anthracyclines and rel

Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

✍ Helen M. Coley; Peter R. Twentyman; Paul Workman 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 804 KB

A range of anthracyclines and related compounds were evaluated for activity against murine and human cell lines exhibiting multidrug resistance (MDR). Cell lines used were the NCI-H69 human small-cell lung cancer line and the EMT6 murine mammary tumour line, together with their multidrug-resistant c