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Monitoring of minimal residual disease (MRD) by real-time quantitative reverse transcription PCR (RQ-RT-PCR) in childhood acute myeloid leukemia with AML1/ETO rearrangement

✍ Scribed by Viehmann, S; Teigler-Schlegel, A; Bruch, J; Langebrake, C; Reinhardt, D; Harbott, J


Book ID
110055496
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
199 KB
Volume
17
Category
Article
ISSN
0887-6924

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Because previous PCR-based methodologies for detection of minimal residual disease (MRD) in leukemia patients have been too cumbersome to allow for widespread clinical usefulness, we have employed a real-time quantitative PCR (RQ-PCR) system to develop an MRD assay for t(12;21). We initially determi