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Monitoring of liquid-phase peptide synthesis on soluble polymer supports via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

✍ Scribed by R. Thürmer; M. Meisenbach; H. Echner; A. Weiler; R. A. Al-Qawasmeh; W. Voelter; U. Korff; W. Schmitt-Sody

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
352 KB
Volume
12
Category
Article
ISSN
0951-4198

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✦ Synopsis

Taking the enkephalin synthesis on soluble polyethylene glycol support as a test case, this communication demonstrates the usefulness of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to monitor each step of coupling as well as removal of the N-terminal protecting group of the polymer-bound growing peptide chain. With minute amounts of sample the high mass accuracy permits detection of side reactions as well as incomplete reaction products.

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