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Monitoring dehydration kinetics using simultaneous thermal and spectral methods

✍ Scribed by Mark A. Beard; Oana R. Ghita; James McCabe; Kenneth E. Evans

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
334 KB
Volume
41
Category
Article
ISSN
0377-0486

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✦ Synopsis

Abstract

The dehydration kinetics of theophylline monohydrate is a two‐stage process. The first stage involves loosening of the crystal water followed by a second stage in which the water evaporates from the sample. During differential scanning calorimetry (DSC) measurements, the kinetics of the two stages can be dramatically altered because of the sample environment and DSC pan type. In‐depth understanding of how the sample environment alters the dehydration process and the kinetics involved requires more than DSC experiments alone. This paper describes the use of a novel, simultaneous thermal and spectral technique to monitor the dehydration kinetics of theophylline monohydrate. The analysis of the results obtained on the combined DSC‐near‐infrared and DSC‐Raman equipment clearly detects the two stages of the dehydration process and the polymorphic structural changes that take place. The combined technique provides a powerful method to monitor the dehydration of hydrous systems. Copyright © 2010 John Wiley & Sons, Ltd.

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