Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream
✍ Scribed by A.D. Ormerod; M.I. White; S.A.A. Shah; N. Benjamin
- Book ID
- 104459288
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 225 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0007-0963
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✦ Synopsis
A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.