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Molecularly imprinted polymers as affinity-based separation media for sample preparation

✍ Scribed by Jun Haginaka

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
803 KB
Volume
32
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

This review article deals with molecularly imprinted polymers (MIPs) as affinity‐based separation media for sample preparation. An over view of two types of MIPs (molecularly imprinted particle and monolith) used for the sample preparation and modes of molecularly imprinted SPE (online mode, offline mode, on‐column extraction, SPME, and microextraction in packed syringe) is given, focusing on the advantages and disadvantages of these types and modes. Next, problems (template leakage and incompatibility with aqueous conditions) associated with molecularly imprinted SPE and how to overcome those problems are described. Finally, pharmaceutical, food, bioanalytical, and environmental application of molecularly imprinted SPE will be discussed.

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Molecularly imprinted polymers have been prepared against aniline and a bis-aniline compound, making use of a crown ether (18-crown-6) to solubilize the monomer-template complexes. Subsequent chromatographic rebinding studies in the absence of crown ether revealed regioselectivity for the templates