Molecular weight alterations of alpha-1 proteinase inhibitor in equine bronchoalveolar lavage fluid

Reduced proteolysis of surfactant protei

Reduced proteolysis of surfactant protein A and changes of the bronchoalveolar lavage fluid proteome by inhaled α1-protease inhibitor in cystic fibrosis

✍ Matthias Griese; Christina von Bredow; Peter Birrer 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 565 KB

In cystic fibrosis (CF), the chronic neutrophilic inflammation of the airways results in proteolytic degradation of lung tissue early in the course of the disease. Inhalation of alpha 1-protease inhibitor (alpha 1-PI) may restore the protease-antiprotease imbalance and thus lead to less tissue damag