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Molecular targets of cancer chemotherapy

โœ Scribed by K. S. Zaenker; G. Mustacchi; E. Mihich

Book ID
105992299
Publisher
Springer
Year
2005
Tongue
English
Weight
171 KB
Volume
58
Category
Article
ISSN
0344-5704

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In 10 human cancer cell lines, the activity of mitomycin C (MMC) was found to be determined by an interplay between activation by DT-diaphorase (DTD) and inactivation by glutathione S-transferase (GST). NADPH/cytochrome P-450 reductase was not responsible for MMC activation and expression of MDR1 (M