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Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response

✍ Scribed by Lee, Y-H; Judge, A D; Seo, D; Kitade, M; Gómez-Quiroz, L E; Ishikawa, T; Andersen, J B; Kim, B-K; Marquardt, J U; Raggi, C


Book ID
109972810
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
734 KB
Volume
30
Category
Article
ISSN
0950-9232

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## Abstract Using comparative proteomic and genomic approaches, the authors identified eukaryotic translation initiation factor 5A (eIF5A) as an oncofetal molecule highly abundant in mouse embryonic livers and human hepatocellular carcinoma (HCC) cell lines. To evaluate the oncogenic role and progn