✦ LIBER ✦
Molecular structure of t-butyloxycarbonyl-Leu-Aib-Pro-Val-Aib-methyl ester, a fragment of alamethicin and suzukacillin: A 310-helical pentapeptide
✍ Scribed by Ch. Pulla Rao; P. Balaram
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1982
- Tongue
- English
- Weight
- 555 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Abstract
The pentapeptide Boc‐Leu‐Aib‐Pro‐Val‐Aib‐OMe, a fragment of alamethicin and suzukacillin, crystallizes in the space group __P__2~1~, with a = 11.034 (2), b = 10.894 (2), c = 15.483 (2) Å, β = 104.80 (2)° and Z = 2. The crystal structure has been solved by direct methods and refined to an R value of 0.069. The peptide backbone folds into a right‐handed 3~10~‐helical conformation, stabilized by two intramolecular 4 → 1 hydrogen bonds between the Leu(1) CO and Val(4) NH and Aib(2) CO and Aib(5) NH groups. The solid‐state conformation is consistent with results of spectroscopic analysis in solution.