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Molecular Structure Analysis of Moclobemide, a Monoamine Oxidase Inhibitor

✍ Scribed by J. Wouters; F. Moureau; B. Norberg; G. Evrard; F. Durant

Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
260 KB
Volume
102
Category
Article
ISSN
0037-9646

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✦ Synopsis

The crystal structure of Moclobemide, p-chloro-N-(2 morpholinoethyl) benzamide is reported and compared with that of Moclobemide hydrochloride monohydrate. There is free rotation of the phenyl ring and the amidic function of the benzamide moeity as confirmed by a conformation analysis performed with the PCILO "Perturbative Conformation Interaction using Localized Orbitals" method. C13H 17N202C1, Mw=268.4, primitif, P-1, a=l 1.569(3), b=13.814(4)& c=10.004(2), a=98.27(2), p=113.87(2), p104.13(2)", V=1363.7A3, Z=2, Dc=1.31 g.cm-3, Mo Ka, h=0.71060A, p=2.32 cm-l, F(000)=568.0, T=293 K, final Rw=O.O80 for 2995 observed reflections (I12 o(1)).

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