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Molecular Simulation of the Binding of Nerve Growth Factor Peptide Mimics to the Receptor Tyrosine Kinase A

✍ Scribed by Berrera, Marco; Cattaneo, Antonino; Carloni, Paolo

Book ID
119920314
Publisher
Biophysical Society
Year
2006
Tongue
English
Weight
340 KB
Volume
91
Category
Article
ISSN
0006-3495

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Nerve growth factor (NGF) initiates the majority of its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. In addition to rapid increases in the phosphorylation of phosphatidylinositol 3Јkinase (PI 3-kinase) and phospholipase C-β₯ and increased ras a