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Molecular simulation of protein aggregation

✍ Scribed by Dusan Bratko; Troy Cellmer; John M. Prausnitz; Harvey W. Blanch

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 554 KB
Volume: 96
Category: Article
ISSN: 0006-3592
DOI: 10.1002/bit.21232

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✦ Synopsis

Abstract

Computer simulation offers unique possibilities for investigating molecular‐level phenomena difficult to probe experimentally. Drawing from a wealth of studies concerning protein folding, computational studies of protein aggregation are emerging. These studies have been successful in capturing aspects of aggregation known from experiment and are being used to refine experimental methods aimed at abating aggregation. Here we review molecular‐simulation studies of protein aggregation conducted in our laboratory. Specific attention is devoted to issues with implications for biotechnology. Biotechnol. Bioeng. 2007;96: 1–8. © 2006 Wiley Periodicals, Inc.

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