Molecular self-recognition and adhesion via proteoglycan to proteoglycan interactions as a pathway to multicellularity: Atomic force microscopy and color coded bead measurements in sponges
✍ Scribed by Misevic, Gradimir N.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 965 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1059-910X
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✦ Synopsis
During the emergence of multicellular organisms, molecular mechanisms evolved to allow maintenance of anatomical integrity and self-recognition. We propose that carbohydrates from proteoglycans, as the most peripheral cell surface, and matrix molecules might have provided these key adhesion and recognition functions. If so, the Porifera as the simplest metazoans alive today should retain, at least in part, proteoglycan adhesion and recognition mechanisms. Early work on cell adhesion of dissociated marine sponge cells provided important phenomenological evidence for cell sorting. Here is reviewed recent work on molecular mechanisms of cell recognition and adhesion mediated by cell surface proteoglycans purified from three marine sponge species,