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Molecular Restraints in the Permeation Pathway of Ion Channels

✍ Scribed by Werner Treptow; Mounir Tarek

Book ID
111691362
Publisher
Biophysical Society
Year
2006
Tongue
English
Weight
747 KB
Volume
91
Category
Article
ISSN
0006-3495

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Modeling of ion permeation in calcium an
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## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr