Molecular requirement for interleukin 1 induction by lipopolysaccharide-stimulated human monocytes: Involvement of the heptosyl-2-keto 3-deoxyoctulosonate region
✍ Scribed by Souad Lebbar; Jean-Marc Cavaillon; Martine Caroff; Annick Ledur; Helmut Brade; Robert Sarfati; Nicole Haeffner-Cavaillon
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 573 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Interleukin 1 induction by the heptosyl(1-5)-KDO region of lipopolysaccharide 87 ing B cell clones, activated in immune responses to external antigens in the small resting population, and cross-reacting with self epitopes, from being hazardous to the individual, not only in the neonatal system but throughout the life-span of the individual. However, the main role of this background-activated high connectivity set might be t o establish and ensure the recursive succession of stable steady states in a dynamic immune system, keeping an "awareness" of its own components and determining its relationships with the rest of the individual self.
We wish to acknowledge the skillful technical assistance of Mss. Odile Burlen and Marie-Pierre Lembezat, and excellent secretarial assistance of Ms. Jacqueline Badella.