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Molecular recognition of p53 and MDM2 by USP7/HAUSP

✍ Scribed by Sheng, Yi; Saridakis, Vivian; Sarkari, Feroz; Duan, Shili; Wu, Tianne; Arrowsmith, Cheryl H; Frappier, Lori


Book ID
109966449
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
447 KB
Volume
13
Category
Article
ISSN
1545-9993

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## Abstract Two 35‐ns molecular dynamics simulations of both ligated [mouse double minute protein 2 (MDM2^p53^)] and unligated (MDM2^apo^) structures of human MDM2 bound to the N‐terminal domain of the tumor suppressor p53 have been performed. Analysis of the dynamics revealed that the most flexibl