Molecular Recognition in Host-Parasite Interactions

✍ Scribed by Elaine I. Tuomanen (auth.), Timo K. Korhonen, Tapani Hovi, P. Helena Mäkelä (eds.)

• Publisher: Springer US
• Year: 1992
• Tongue: English
• Leaves: 229
• Series: Federation of European Microbiological Societies Symposium Series 61
• Edition: 1
• Category: Library

✦ Synopsis

A very early step in microbial colonization and pathogenesis is that involving recog­ nition of the host by the microbe. In the final analysis such recognition is due to interaction between specific molecules on the two sides, without which host and microbe would ignore each other. It is therefore exciting to learn the rules that govern host-microbe interaction at to a large extent determines whether or not we are infected by the molecular level, which influenza virus, leishmanias, staphylococci and other pathogens. This book is a compendium of the addresses delivered at a symposium on molecular interaction at Porvoo, Finland in August 1991. Realizing that there are no a priori differ­ ences in receptor recognition in viruses, eukaryotic parasites and bacteria, we freely inter­ mingled these microbes at the symposium, and in this book. We found the interdisciplinary discussions and comparisons both educative and stimulating. Thus the book is divided into parts that focus on host cell receptors, on microbial recognition molecules and molecules that mediate microbial interaction with a host cell receptor and, briefly, on the molecular events that follow. Although many microbes and many cellular receptors are missing from the book -owing to the limited duration and size of the symposium -the articles presented here constitute an impressive body of examples of how initial host-microbe interaction can come about. We believe that as such the book is a useful and interesting overview of the mechanisms and principles involved in these interactions.

✦ Table of Contents

Front Matter....Pages i-ix
Biology of Adhesins of Bordetella Pertussis : Integrins, Selectins, and Mimicry of Leukocyte Adherence to Endothelia....Pages 1-6
Structure-Function Relationships of the Reovirus Cell-Attachment Protein σ1....Pages 7-16
Macrophage Receptors and Leishmania ....Pages 17-30
Streptococcal M Protein: A Common Structural Motif Used by Gram-Positive Bacteria for Biologically Active Surface Molecules....Pages 31-38
Properties and Synthesis of K88 Fimbriae....Pages 39-46
Function and Organization of Escherichia Coli Adhesins....Pages 47-55
Fibronectin-Binding Proteins of Staphylococci and Streptococci....Pages 57-64
S-Layers in Bacterial Pathogenesis: The Tetragonal Paracrystalline Surface Protein Array of Aeromonas Salmonicida as a Special Example....Pages 65-75
Streptococcal IgA Receptors....Pages 77-83
Molecular Investigation of Escherichia Coli Virulence in Extraintestinal Infections....Pages 85-91
Multifunctional Nature of Enterobacterial Fimbriae....Pages 93-100
Virus Interaction with Host Cell Receptors: Does gp120 of Human Immunodeficiency Virus Resemble an MHC Class II Alloepitope?....Pages 101-106
Role of Cell Receptors for Poliovirus in Pathogenesis, Host Range and Virus Entry....Pages 107-113
Membrane Proximity and Internal Binding in the Microbial Recognition of Host Cell Glycolipids: A Conceptual Discussion....Pages 115-132
Bacterial Adherence and Host Tropism in Escherichia Coli ....Pages 133-138
Role of Interactions between Cytomegalovirus and ß 2 -Microglobulin in the Pathogenesis of Infection....Pages 139-144
Complement Activation and Use of Complement Receptors for Cell Entry in Salmonellosis....Pages 145-152
Binding and Activation of Plasminogen on the Surface of Staphylococcus Aureus and Group A, C, and G Streptococci....Pages 153-162
Escherichia Coli S Fimbriae: Oligosaccharide-Specific Binding to Host Tissues and Enhancement of Plasminogen Activation....Pages 163-171
Recognition Molecules on Red Cells for Malarial Parasites....Pages 173-182
Inhibitory Action of Amantadine during Influenza Viral Entry: A Hypothesis....Pages 183-190
Effect of Host Proteases on Early Steps of Enterovirus Infection....Pages 191-200
Proteolytic Activation of Influenza Viruses: Substrates and Proteases....Pages 201-209
Regulation of the Entry into Host Cytoplasm and Cell-to-Cell Spread of Listeria Monocytogenes ....Pages 211-219
Protein Translocation from the Exterior to the Cytosol: Diphtheria Toxin as a Model System....Pages 221-225
Back Matter....Pages 227-230

✦ Subjects

Immunology; Infectious Diseases; Medical Microbiology; Plant Sciences; Animal Anatomy / Morphology / Histology; Microbial Ecology