Molecular Recognition and Adhesion of Individual DNA Strands Studied by Dynamic Force Microscopy

✍ Scribed by Wilfried Grange; Torsten Strunz; Irina Schumakovitch; Hans-Joachim Güntherodt; Martin Hegner

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 151 KB
• Volume: 2
• Category: Article
• ISSN: 1438-5163
• DOI: 10.1002/1438-5171(200107)2:2<75::aid-simo75>3.0.co;2-8

✦ Synopsis

The development of versatile scanning probe methods such as atomic force microscopy (AFM) makes it today possible to study bio-adhesion on a single molecule level. In this paper, we present AFM-force-spectroscopy experiments on complementary DNA strands. From such experiments, intrinsic thermodynamical properties (energy landscape) of these weak non covalent bonds can be determined.