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Molecular purging of multiple myeloma cells byex-vivoculture and retroviral transduction of mobilized-blood CD34+cells

✍ Scribed by Sara Deola; Samantha Scaramuzza; Roberto Sciarretta Birolo; Massimiliano Cergnul; Francesca Ficara; Jonathan Dando; Claudia Voena; Sergio Vai; Marta Monari; Enrico Pogliani; Gianmarco Corneo; Jacopo Peccatori; Silvia Selleri; Claudio Bordignon; Maria Grazia Roncarolo; Alessandro Aiuti; Marco Bregni


Book ID
119905455
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
733 KB
Volume
5
Category
Article
ISSN
1479-5876

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Targeted transduction of CD34+ hematopoi
✍ Min Liang; Nonia Pariente; Kouki Morizono; Irvin S. Y. Chen πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 973 KB

## Abstract ## Background Conventional gene‐therapy applications of hematopoietic stem cells (HSCs) involve purification of CD34+ progenitor cells from the mobilized peripheral blood, __ex vivo__ transduction of the gene of interest into them, and reinfusion of the transduced CD34+ progenitor cell