Molecular purging of multiple myeloma cells byex-vivoculture and retroviral transduction of mobilized-blood CD34+cells
β Scribed by Sara Deola; Samantha Scaramuzza; Roberto Sciarretta Birolo; Massimiliano Cergnul; Francesca Ficara; Jonathan Dando; Claudia Voena; Sergio Vai; Marta Monari; Enrico Pogliani; Gianmarco Corneo; Jacopo Peccatori; Silvia Selleri; Claudio Bordignon; Maria Grazia Roncarolo; Alessandro Aiuti; Marco Bregni
- Book ID
- 119905455
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 733 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1479-5876
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## Abstract ## Background Conventional geneβtherapy applications of hematopoietic stem cells (HSCs) involve purification of CD34+ progenitor cells from the mobilized peripheral blood, __ex vivo__ transduction of the gene of interest into them, and reinfusion of the transduced CD34+ progenitor cell