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Molecular processes of chromosome 9p21 deletions in human cancers

โœ Scribed by Sasaki, Shigeru; Kitagawa, Yukiko; Sekido, Yoshitaka; Minna, John D; Kuwano, Hiroyuki; Yokota, Jun; Kohno, Takashi

Book ID
110067687
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
292 KB
Volume
22
Category
Article
ISSN
0950-9232

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We examined 149 lung cancer cell lines for homozygous deletions using 24 DNA markers, which were mapped and ordered in chromosome band 9p21, to define the target regions for 9p21 deletions in human lung cancer. Homozygous deletions were detected in 39 (26%) cell lines and clustered at 2 independent

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Chromosome 9p has been reported to be a critical region of loss in various cancers. Our present study was designed to determine the frequency of deletions at different loci of chromosome 9p in microdissected samples of normal prostatic epithelium and carcinoma from the same patients. For this purpos