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Molecular predictive factors of response to anti-EGFR antibodies in colorectal cancer patients

✍ Scribed by Daniele Santini; Francesco Pantano; Bruno Vincenzi; Fotios Loupakis; Michele Caraglia; Alfredo Falcone; Giuseppe Tonini


Book ID
119233639
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
123 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract __KRAS__ mutations are a strong predictive marker of resistance to anti‐epidermal growth factor receptor (EGFR) antibodies in advanced colorectal cancer (CRC) but only a subset of wild‐type (WT) __KRAS__ patients are responders, suggesting the existence of additional markers of resistan