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Molecular piracy: manipulation of the ubiquitin system by Kaposi's sarcoma-associated herpesvirus

✍ Scribed by Masahiro Fujimuro; S. Diane Hayward; Hideyoshi Yokosawa

Book ID
104590609
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
363 KB
Volume
17
Category
Article
ISSN
1052-9276

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✦ Synopsis

Abstract

Ubiquitination, one of several post‐translational protein modifications, plays a key role in the regulation of cellular events, including protein degradation, signal transduction, endocytosis, protein trafficking, apoptosis and immune responses. Ubiquitin attachment at the lysine residue of cellular factors acts as a signal for endocytosis and rapid degradation by the 26S proteasome. It has recently been observed that viruses, especially oncogenic herpesviruses, utilise molecular piracy by encoding their own proteins to interfere with regulation of cell signalling. Kaposi's sarcoma‐ associated herpesvirus (KSHV) manipulates the ubiquitin system to facilitate cell proliferation, anti‐apoptosis and evasion from immunity. In this review, we will describe the strategies used by KSHV at distinct stages of the viral life‐cycle to control the ubiquitin system and promote oncogenesis and viral persistence. Copyright © 2007 John Wiley & Sons, Ltd.

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