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Molecular pharmacology of 5-HT1Drecognition sites: Radioligand binding studies in human, pig and calf brain membranes

✍ Scribed by C. Waeber; P. Schoeffter; J. M. Palacios; D. Hoyer


Book ID
112276513
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
734 KB
Volume
337
Category
Article
ISSN
0028-1298

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High-affinity, specific 3H-5-hydroxytryptamine (5-HT) binding was analyzed in membrane homogenates of human frontal cortex, caudate, and globus pallidus. 5-HT1A and 5-HT1C binding sites were pharmacologically blocked using 100 nM 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) and 100 nM mesulerg