Molecular Pathology in Clinical Practice

✍ Scribed by Debra G.B. Leonard (eds.)

Publisher: Springer International Publishing
Year: 2016
Tongue: English
Leaves: 989
Edition: 2
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues.

The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

✦ Table of Contents

Front Matter....Pages i-xix
Basics of Molecular Biology....Pages 1-17
Molecular Pathology Methods....Pages 19-52
Front Matter....Pages 53-54
Genetic Counseling....Pages 55-62
Pedigree Analysis and Risk Assessment....Pages 63-76
Bayesian Analysis....Pages 77-89
Intellectual Disability and Developmental Delay: Cytogenetic Testing....Pages 91-100
Developmental Delay: Gene Testing....Pages 101-119
Congenital Disorders of Glycosylation....Pages 121-125
Neuromuscular Diseases....Pages 127-138
Mitochondrial Disorders....Pages 139-159
Metabolic Disorders....Pages 161-175
Fibroblast Growth Factor Receptor and Related Skeletal Disorders....Pages 177-187
Cystic Fibrosis....Pages 189-196
Deafness....Pages 197-201
Coagulation Disorders....Pages 203-223
Hematologic Disorders: Hemochromatosis, Hemoglobinopathies, and Rh Incompatibility....Pages 225-238
Cardiovascular Disease....Pages 239-259
Neurodegenerative Disorders....Pages 261-276
Polycystic Kidney Disease....Pages 277-290
Host Factor Pharmacogenetics for Treatment of Infectious Diseases....Pages 291-300
Front Matter....Pages 53-54
Pharmacogenetics....Pages 301-312
Front Matter....Pages 313-314
Inherited Breast Cancer....Pages 315-327
Familial Adenomatous Polyposis and Turcot and Peutz–Jeghers Syndromes....Pages 329-337
Hereditary Nonpolyposis Colorectal Cancer and Lynch Syndrome....Pages 339-350
Multiple Endocrine Neoplasia Syndromes....Pages 351-363
Von Hippel-Lindau Disease....Pages 365-368
Hereditary Skin Cancer....Pages 369-375
Li-Fraumeni Syndrome....Pages 377-383
Retinoblastoma....Pages 385-392
Hereditary Paraganglioma and Pheochromocytoma....Pages 393-399
Front Matter....Pages 401-402
Colorectal Cancer....Pages 403-417
Lung Cancer....Pages 419-432
Breast Cancer....Pages 433-446
Urothelial Carcinoma....Pages 447-452
Prostate Cancer....Pages 453-469
Thyroid Cancer....Pages 471-485
Sarcomas and Related Mesenchymal Tumors....Pages 487-506
Gliomas....Pages 507-514
Molecular Detection of Circulating Tumor Cells and Cell-Free Nucleic Acids....Pages 515-523
Front Matter....Pages 525-526
Acute Myeloid Leukemia....Pages 527-559
Front Matter....Pages 525-526
Acute Lymphoblastic Leukemia....Pages 561-577
B-Cell Malignancies....Pages 579-602
T-Cell Lymphomas....Pages 603-614
Myeloproliferative Neoplasms and Myelodysplastic Syndromes....Pages 615-626
Front Matter....Pages 627-628
Human Immunodeficiency Virus Type 1....Pages 629-640
Hepatitis B and C Viruses....Pages 641-657
Viral Infections in Transplant Recipients....Pages 659-679
Viral Infections of the Central Nervous System....Pages 681-694
Bacterial Infections....Pages 695-706
Gastrointestinal Infections....Pages 707-734
Sexually Transmitted Diseases....Pages 735-753
Respiratory Infections....Pages 755-778
Mycobacterial Infections....Pages 779-789
Front Matter....Pages 791-792
Forensic DNA Typing....Pages 793-810
Parentage and Relationship Testing....Pages 811-821
Chimerism Testing in Allogeneic Hematopoietic Stem Cell Transplantation....Pages 823-848
Specimen Identification Through DNA Analysis....Pages 849-864
Front Matter....Pages 865-866
Molecular HLA Typing....Pages 867-885
Front Matter....Pages 887-888
Next-Generation Sequencing: Principles for Clinical Application....Pages 889-909
Next-Generation Sequencing for the Analysis of Cancer Specimens....Pages 911-931
Front Matter....Pages 887-888
Clinical Applications of Proteomics....Pages 933-941
Front Matter....Pages 943-944
Molecular Pathology Laboratory Management....Pages 945-973
Back Matter....Pages 975-1001

✦ Subjects

Pathology; Oncology; Human Genetics

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