Chronic liver inflammation and hepatic regeneration by infection with hepatitis B (HBV) or C virus (HBC) seem to be important risk factors for hepatocellular carcinoma (HCC). Regarding the hepatocarcinogenesis of HBV DNA integration, it has been variously hypothesized that mechanisms such as the alt
✦ LIBER ✦
Molecular pathogenesis and early detection of hepatocellular carcinoma – Perspectives from West Africa
✍ Scribed by Maimuna Mendy; Robert Walton
- Book ID
- 116335252
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 249 KB
- Volume
- 286
- Category
- Article
- ISSN
- 0304-3835
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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGG→AGT at codon 249, Arg→Ser) has been identified as a hotspot in HCCs from such areas,