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Molecular, oncologic, and therapeutic spectrum of von Hippel-Lindau disease

✍ Scribed by H. H. Goebel


Book ID
106284110
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
10 KB
Volume
23
Category
Article
ISSN
0344-5607

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Genetic analysis of von Hippel-Lindau di
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Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital polycythemia, and are found in many sporadic tumor types as well. Reports of VHL mutations are dispersed throughout original articles and databases that have not been recently updated. We compiled a comprehensi

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## Abstract Deletions of 3p25, gains of chromosomes 7 and 10, and isochromosome 17q are known cytogenetic aberrations in sporadic renal cell carcinoma (RCC). In addition, a majority of RCCs have loss of heterozygosity (LOH) of the Von Hippel‐Lindau (__VHL__) gene located at chromosome band 3p25. Pa