the Use Of Targeted Cytotoxins To Make Highly Selective Neural Lesions For Both Experimental And Clinical Purposes Has Already Provided Important Animal Models For Diseases Such As Alzheimer's, And Holds Great Promise For Research And Clinical Application To Pain. In Molecular Neurosurgery With Targeted Toxins, Pioneers In The Field Describe Their Hands-on Experience With The Experimental Use Of These Toxins. The Authors Focus On The Highly Successful Use Of The Immunotoxins, 192 Igg-saporin And Me20.4-saporin, To Lesion The Cholinergic Basal Forebrain In Order To Model The Behavior, Anatomy, Physiology, And Pharmacology Of Alzheimer's Disease In Animals. Also Discussed Are The Uses Of Anti-dbh-saporin Immunotoxin To Make Remarkably Selective Lesions Of Catecholaminergic Neurons, Hypocretin-saporin That Can Produce Narcoleptic Animals, And Other Saporin Conjugates, Such As Neuropeptide-saporin Conjugates For Pain Research And Cholera Toxin B Chain-saporin To Produce A Model Of Central Nervous System Demyelination. Overview Perspectives And, In Some Cases, More Practical Details Are Provided That Allow The Reader To Appreciate Exactly What Is Involved In Using These Agents.
both Practical And Theoretical, Molecular Neurosurgery With Targeted Toxins Provides Readers With Not Only The Background To Understand These Techniques, But Also Numerous Real-life Examples That Can Be Readily Adapted To New Purposes And An Ever-increasing Number Of New Targeted Toxins.
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**reviewer:**celso Agner, Md, Msc(university Of Illinois At Chicago College Of Medicine)
**description:**molecular Biology Has Been Contributing To The Development Of Newer Medications And Targeted Drugs For The Nervous System. This Book Addresses New Avenues Of Treatment In Neurosurgery With Targeted Drugs.
**purpose:**the Purpose Is To Integrate The Concepts Derived From Targeted Lesions And Stimulation To The Central Nervous System And Different Drugs Developed From Previous Decades Of Research.
**audience:**neurologists, Neuroscientists, And Neurosurgeons Are The Main Audience For This Book.
**features:**multiple Contributors Wrote The 13 Chapters. Although Mostly Dedicated To The Basic Sciences, This Book Addresses Multiple Potential Clinical Applications Of The Targeted Research Being Developed. The Pictures Are Well Chosen And The Text, Easy To Follow. The Price Is A Bit Too High But Encompasses The Years Of Research Devoted By The Authors And Contributors.
**assessment:**this Is A Good Purchase For Most Neuroscience And Neurology Libraries. It Is Less Appropriate For Neurosurgical Libraries.