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Molecular modelling of inhibitors of aromatase — a novel approach

✍ Scribed by Sabbir Ahmed; Paul J Davis

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
257 KB
Volume
5
Category
Article
ISSN
0960-894X

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The authors developed a breast cancer intratumoral aromatase model system to compare the antitumor efficacy of several aromatase inhibitors (AIs) and antiestrogens (AEs). Although the AI letrozole caused sustained growth inhibition, tumors eventually began to grow, even when treatment was maintained