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Molecular Modeling Studies on G-Quadruplex Complexes of Telomerase Inhibitors: Structure−Activity Relationships

✍ Scribed by Read, Martin A.; Wood, Alexis A.; Harrison, John R.; Gowan, Sharon M.; Kelland, Lloyd R.; Dosanjh, Harvinder S.; Neidle, Stephen


Book ID
118185494
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
581 KB
Volume
42
Category
Article
ISSN
0022-2623

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Here we report that human telomere guanine-rich sequence AGGG(TTAGGG) 3 (G4) and hemin can form a G-quadruplex-hemin complex (GHC) which exhibits good electrochemical characteristics. The redox signals of the complex and the electrocatalytic activities toward the reduction of hydrogen peroxide have