𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular modeling of the three-dimensional structure of the extracellular loops of the CCK2receptor and their binding with the CCK-4 tetrapeptide

✍ Scribed by P. E. Kuznetsov; N. B. Kuznetsova; S. V. Shul’gin; A. V. Shantrokha; E. N. Dubas

Publisher
Springer
Year
2008
Tongue
English
Weight
248 KB
Volume
42
Category
Article
ISSN
0091-150X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structural mechanisms of constitutive ac
Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: Molecular modeling study
✍ Gregory V. Nikiforovich; Thomas J. Baranski 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 641 KB

## Abstract Previously we demonstrated by random saturation mutagenesis a set of mutations in the extracellular (EC) loops that constitutively activate the C5a receptor (C5aR) (Klco et al., Nat Struct Mol Biol 2005;12:320–326; Klco et al., J Biol Chem 2006;281:12010–12019). In this study, molecular

Differential Virtual Screening (DVS) wit
Differential Virtual Screening (DVS) with Active and Inactive Molecular Models for Finding and Profiling GPCR Modulators: Case of the CCK1 Receptor
✍ Constantino Diaz; Pascal Leplatois; Patricia Angelloz-Nicoud; Marinette Lecomte; 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 915 KB

## Abstract We discovered a constitutively activating mutation (CAM) V308E for the neurotensin NT1 receptor. Molecular dynamics (MD) performed for the CAM NT1‐V308E exhibiting a high spontaneous activity, and for the wild‐type NT1 without basal activity, show dramatic conformational changes for the