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Molecular modeling of novel 1H-pyrazolo[3,4-b]pyridine derivatives designed as isosters of the antimalarial mefloquine

✍ Scribed by Carla Maria S Menezes; Carlos Mauricio R Sant'Anna; Carlos Rangel Rodrigues; Eliezer J Barreiro


Book ID
114141763
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
480 KB
Volume
579
Category
Article
ISSN
0166-1280

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Studies on the acetylation of 3,6-diamin
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The acetylation reaction of the differently substituted 3,6-diamino-1H-pyrazolo [3,4-b]pyridine-5-carbonitrile derivatives 1-6 is reported. The structure of the resulting acetamides has been investigated and confirmed by analytical, spectroscopic, and chemical transformations. From these studies, we