In a number of membrane-bound viruses, ion channels are formed by integral membrane proteins. These channel proteins include M2 from influenza A, NB from influenza B, and, possibly, Vpu from HIV-1. M2 is important in facilitating uncoating of the influenza A viral genome and is the target of amantad
โฆ LIBER โฆ
Molecular modeling of ion channels: structural predictions
โ Scribed by Alejandro Giorgetti; Paolo Carloni
- Book ID
- 104414624
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 175 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1367-5931
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โฆ Synopsis
Recent advances in membrane protein crystallography have greatly increased structural information of channels permeating metal ions. Structural bioinformatics techniques and molecular dynamics calculations are providing structural models of ion channels for which the three-dimensional structure is not known. Most of the reported structure prediction studies focus on K(+) channels and are based on the KcsA K(+) channel structure.
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