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Molecular Modeling, a Tool for Predicting Structural Effects on the Macrocyclization Reaction between Bis(vinyl or allyl) Dialdehydes and Thiophosphonic Bis(hydrazides)

✍ Scribed by Galliot, Christophe ;Caminade, Anne-Marie ;Majoral, Jean Pierre ;Kuznikowski, Maciej ;Zablocka, Maria ;Pietrusiewicz, K. Michal


Book ID
102791670
Publisher
Wiley (John Wiley & Sons)
Year
1995
Tongue
English
Weight
537 KB
Volume
128
Category
Article
ISSN
0009-2940

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✦ Synopsis


Phosphorus macrocycles / Molecular modeling / Cyclocondensation

The reaction of new phosphorus dialdehydes PhP(0)-spectively. Molecular modeling of 4a-c, 5a, 6 and of the in-[(CH2),CH=CHCGH4CHOJz (4a-c, 5a) (n = 0:4, n = 15; termediate monocondensation products ?a-c, 8a was carried a:para, b:meta, c:ortho), with thiophosphonic bis(hydrazide) out and points out the importance of the geometry of the PhP(S)[NMeNHzl2 (6) yields macrocyclic compounds Sb', c', starting reagents in the competition between inter-and intraloaf, Sa", b , c", 10a" and Qc"', arising from the cycloconden-molecular cyclocodensation. sation of one, two, or three equivalents of each reagent, re-