Molecular methods for the study of the genetic determinants of nephropathy in type 1 (insulin-dependent) diabetes
β Scribed by A. Doria; J. H. Warram; A. S. Krolewski
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 852 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0940-5429
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We performed a follow-up study of the glomerular function in a series of 29 Type 1 (insulin-dependent) diabetic patients who had been studied 18 years previously. Initial median duration of diabetes was 2 years (range 0-9) and at follow-up 21 (17-27) years. At follow-up, 8 diabetic patients exhibite
The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in