The assembly of intermediate filaments is a fundamental property of the central rod domain of the individual subunit proteins. This rod domain, with its high propensity for a-helix formation, is the common and identifying feature of this Family of proteins. Assembly occurs in vitro in the absence of
Molecular mechanisms underlying the assembly of intermediate filaments
โ Scribed by Laurent Kreplak; Ueli Aebi; Harald Herrmann
- Book ID
- 118505933
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 310 KB
- Volume
- 301
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Together with microtubules and actin microfilaments, approximately 11 nm wide intermediate filaments (IFs) constitute the integrated, dynamic filament network present in the cytoplasm of metazoan cells. This network is critically involved in division, motility and other cellular processes. While the
Intermediate-filament forming proteins are known to form rod-shaped dimers that are calculated to be 45 nm in length. Molecular modeling indicates that the dimerization is promoted by interchain hydrophobic interactions between sections of (Y helix and p helix. Further aggregation involves the forma