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Molecular mechanisms underlying the assembly of intermediate filaments

โœ Scribed by Laurent Kreplak; Ueli Aebi; Harald Herrmann


Book ID
118505933
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
310 KB
Volume
301
Category
Article
ISSN
0014-4827

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Intermediate-filament forming proteins are known to form rod-shaped dimers that are calculated to be 45 nm in length. Molecular modeling indicates that the dimerization is promoted by interchain hydrophobic interactions between sections of (Y helix and p helix. Further aggregation involves the forma