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Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors

โœ Scribed by Shin-ichiro Miura; Yoshino Matsuo; Yoshihiro Kiya; Sadashiva S. Karnik; Keijiro Saku


Book ID
116299438
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
391 KB
Volume
391
Category
Article
ISSN
0006-291X

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โœ E. Galvez-Ruano; K. B. Lipkowitz; Prof. M. H. Aprison ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 578 KB

We used molecular modeling techniques to examine six reported antagonists of glycine with varying K, values against strychnine. We found the data suggest two groups operating with different mechanisms. In group 1 (strychnine, brucine, Pitrazepin, and bicuculline methobromide) the antagonist contains