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Molecular mechanisms of inherited demyelinating neuropathies

✍ Scribed by Steven S. Scherer; Lawrence Wrabetz

Book ID
102224474
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
360 KB
Volume
56
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

The past 15 years have witnessed the identification of more than 25 genes responsible for inherited neuropathies in humans, many associated with primary alterations of the myelin sheath. A remarkable body of work in patients, as well as animal and cellular models, has defined the clinical and molecular genetics of these illnesses and shed light on how mutations in associated genes produce the heterogeneity of dysmyelinating and demyelinating phenotypes. Here, we review selected recent developments from work on the molecular mechanisms of these disorders and their implications for treatment strategies. Β© 2008 Wiley‐Liss, Inc.

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