Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia
β Scribed by Silvia Pastorekova; Peter J. Ratcliffe; Jaromir Pastorek
- Book ID
- 109054021
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 200 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1464-4096
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The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the rel
In the present study, we investigated the role of the extracellular signal-regulated protein kinase (ERK) in regulation of the hypoxia marker, carbonic anhydrase IX (CAIX). U0126, a specific inhibitor of MEK1/2, downregulated CAIX expression induced by true hypoxia and cell density. CA9 promoter act