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Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxide-dependent and -independent action

โœ Scribed by Yoshiro Saito; Keiko Nishio; Yoko Ogawa; Tomoya Kinumi; Yasukazu Yoshida; Yoshinori Masuo; Etsuo Niki


Book ID
113630206
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
1021 KB
Volume
42
Category
Article
ISSN
0891-5849

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Activation of proteolytic enzymes, including the caspase family of proteinases, is a feature characteristic of the apoptotic program. In the present study, we examined a potential role of intracellular proteinases in the death of neuronal PC12 and primary cultured rat microglial cells induced by 6-h