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Molecular mechanisms behind the resistance of cisplatin in germ cell tumours

✍ Scribed by Josep Ma. Piulats; Laura Jiménez; Xavier García del Muro; Alberto Villanueva; Francesc Viñals; José R. Germà-Lluch

Book ID
107597585
Publisher
Springer Milan
Year
2009
Tongue
Spanish
Weight
339 KB
Volume
11
Category
Article
ISSN
1699-048X

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Cisplatin (CDDP) is an extremely active drug in the treatment of germ-cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germcell-tumour and 3 colon-carcinoma cell lines. Major components of the s