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Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5

✍ Scribed by Motohiko Oshima; Junsei Mimura; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama

Book ID: 116295767
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 619 KB
Volume: 364
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.09.131

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## Abstract The TGF‐β signaling pathway has potent anti‐mitogenic effects in epithelial cells and loss of negative growth regulation is often associated with increased tumorigenicity. The human pancreatic ductal adenocarcinoma cell line, UK Pan‐1, which expresses __DPC4__, is not highly responsive