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Molecular Mechanism of the Sea Anemone Toxin ShK Recognizing the Kv1.3 Channel Explored by Docking and Molecular Dynamic Simulations

✍ Scribed by Jin, Ling; Wu, Yingliang


Book ID
126097312
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
301 KB
Volume
47
Category
Article
ISSN
0095-2338

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Molecular mechanism of δ-dendrotoxin–pot
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d-Dendrotoxin, isolated from mamba snake venom, has 57 residues cross-linked by three disulfide bridges. The protein shares a pharmacological activity with other animal toxins, the potent blockade of potassium channels, but is structurally unrelated to toxins of different species. We employed alanin