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Molecular mechanism of pore formation by actinoporins

✍ Scribed by Katarina Črnigoj Kristan; Gabriella Viero; Mauro Dalla Serra; Peter Maček; Gregor Anderluh

Book ID
116922408
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
917 KB
Volume
54
Category
Article
ISSN
0041-0101

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✍ Anderluh, Gregor; Lakey, Jeremy 📂 Article 📅 2010 🏛 Springer New York 🌐 English ⚖ 377 KB

Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid mem