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Molecular mechanism of drug photosensitization 4. Photohemolysis sensitized by carprofen

✍ Scribed by G. De Guidi; R. Chillemi; L.L. Costanzo; S. Giuffrida; G. Condorelli


Book ID
108044083
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
894 KB
Volume
17
Category
Article
ISSN
1011-1344

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Molecular mechanism of drug photosensiti
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Red blood cell lysis photosensitized by Suprofen (SPF) and the photolysis of the drug were investigated. The photohemolysis process occurs at a higher rate in anaerobic than aerobic conditions. The effect of additives demonstrates the involvement of free radicals and, to a lesser extent, singlet oxy

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The lysis of red blood cells photosensitized by diflunisal (DFN) was investigated. Photohemolysis is inhibited by butylated hydroxyanisole and reduced glutathione, but is unaffected by mannitol and enhanced by sodium azide; the presence of oxygen markedly reduces the lysis which is accelerated in an

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The photosensitizing properties of tolmetin, 5-(p-toluoyl)-1-methyl-2-pyrrolyacetic acid (TLM), have been studied in vitro following the lysis of erythrocytes in phosphate buffer suspensions irradiated with UVA light in the presence of the drug. It was found that the phototoxic properties of the dru