We present a new approach for determining dynamical domains in large proteins, either based on a comparison of different experimental structures, or on a simplified normal mode calculation for a single conformation. In a first step, a deformation measure is evaluated for all residues in the protein;
Molecular Mechanism of Domain Swapping in Proteins: An Analysis of Slower Motions
β Scribed by Kundu, Sibsankar; Jernigan, Robert L.
- Book ID
- 119988723
- Publisher
- Biophysical Society
- Year
- 2004
- Tongue
- English
- Weight
- 413 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0006-3495
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Molecular motions in polyarylates synthesized from substituted bisphenols have been investigated by dynamic mechanical analysis. Substitution at the ring carbon atom results in a more pronounced enhancement in glass transition temperature (__T__~__g__~) as compared to substitution at th
Model-free methods are introduced to determine quantities pertaining to protein domain motions from normal mode analyses and molecular dynamics simulations. For the normal mode analysis, the methods are based on the assumption that in low frequency modes, domain motions can be well approximated by m