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Molecular Mechanism for Low pH Triggered Misfolding of the Human Prion Protein †

✍ Scribed by DeMarco, Mari L.; Daggett, Valerie

Book ID
127125579
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
497 KB
Volume
46
Category
Article
ISSN
0006-2960

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Molecular dynamics simulations of human α-lactalbumin: Changes to the structural and dynamical properties of the protein at low pH
✍ Lorna J. Smith; Christopher M. Dobson; Wilfred F. van Gunsteren 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB 👁 1 views

Two 700-ps molecular dynamics simulations of human ␣-lactalbumin have been compared. Both were initiated from an X-ray structure determined at pH 6.5. One simulation was designed to represent native conditions and the other the protein in solution at pH 2.0 without a bound calcium ion. The low pH co