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Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

✍ Scribed by Ken Itoh; Kit I Tong; Masayuki Yamamoto

Book ID
113629176
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
326 KB
Volume
36
Category
Article
ISSN
0891-5849

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## Abstract **Background:** Transcription factor Nrf2 regulates the expression of a set of detoxifying and anti‐oxidant enzyme genes. Several lines of evidence suggest that electrophiles and reactive oxygen species liberate Nrf2 from its cytoplasmic repressor Keap1 and provoke the accumulation of N