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Molecular mechanics study of myelin basic protein

โœ Scribed by Richard D. Gilliom; Gerald L. Stoner

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
316 KB
Volume
8
Category
Article
ISSN
0192-8651

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โœฆ Synopsis

Myelin basic protein (MBP) is the major extrinsic protein of the myelin sheath in the central nervous system. We have examined the predicted structure of segments of MBP using the molecular mechanics program ECEPP83 developed by Scheraga and coworkers as modified by Chuman, Momany, and Schafer. We have focused upon segments containing the Pro-Pro-Pro sequence (residues 100-102), which have been predicted from standard algorithms to exist in a hairpin loop connecting anti-parallel beta-strands. Both the shorter (98-105, 99-105, and 100-105) and longer segments (87-109, 87-118, and 87-120) have been examined. These results indicate potential for a chain reversal in this region. The shorter segments have been studied by others using NMR techniques and the results are compared.

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