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Molecular mechanics modelling of Pt(II) complexes with antitumor activity. Influence of the type and the positions of the ring substituents on the conformational energies and thermodynamic stabilities

✍ Scribed by I. Georgieva; N. Trendafilova


Publisher
Springer Vienna
Year
1997
Tongue
English
Weight
866 KB
Volume
128
Category
Article
ISSN
0026-9247

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Mechanistic information on the reaction
✍ M. Shoukry; H. Hohmann; R. van Eldik πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 572 KB

The reaction of Pd(Me,en)Cl, (Me,en =N,N,iV',N'-tetramethylethylenediamine) with inosine and 5'-inosine monophosphate was studied as a function of chloride concentration and pH. Evidence for the formation of a 1:l complex with these nucleophiles is presented, and the kinetic data indicate that Pd(Me